hIL5 Effector Reporter Cell
CBP74182
| I. Background | |
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白细胞介素 5（IL5）是 Th2（2 型炎症因子）细胞因子成员，主要由活化的 Th2、肥 大细胞及嗜酸性粒细胞分泌，在嗜酸性粒细胞的生成、活化及生存调控中起核心作用。IL5 目前被认为是 Th2 通路的关键驱动因子之一，在自身免疫疾病中扮演重要角色。 |
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| II. Description | |
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IL5 Effector Reporter Cell 报告基因药靶模型很好的模拟了体内 IL5 的信号转导过程， 原理见下图所示。
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| III. Introduction | |
| Expressed gene: | IL5R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | EDF, IL-5, TRF, Il-5, IL5, interleukin 5, IL5, Il5; |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+200 μg/ml Hygromycin B+2 μg/ml Puromycin+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
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Figure 2. Recombinant hIL5 Effector Reporter Cell constitutively expressing IL5. |
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Figure 3. Dose Response of Recombinant Human IL5 in lL5 Effector Reporter Cell (C9). |
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Figure 4. Inhibition of hlL5-induced Reporter Activity by Abs in lL5 Effector Reporter Cell (C9). |
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